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P1‐514: The ability to design a proxy for consent to treatment and for voting with Alzheimer's disease: preliminary results of a multicenter study.
Author(s) -
Benisty Sarah,
Verny Marc,
ThomasAnterion Catherine,
PerretGuillaume Christine,
Paulin Marion,
El Massioui Farid,
Salomon Laurence,
Mahé Isabelle
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.796
Subject(s) - proxy (statistics) , voting , informed consent , medicine , disease , correlation , mann–whitney u test , psychology , pathology , statistics , mathematics , alternative medicine , geometry , politics , political science , law
Span Backwards plus Attention and Calculation, Color Trails 1 plus 2, ADAS-Cog, Attention and Calculation, Letter Fluency plus Category Fluency, and Color Trails 2. Several neuropsychological tests’ score distributions did not overlap completely (examples: Category Fluency, Digit Span Backwards, Color Trails 1), with worst and best scores uniquely associated with fast decliners and improvers respectively. Measures with restricted or narrow ranges did not have unique values, examples: MMSE and Attention and Calculation. Conclusions: Consistent with the known relationship between severity and rate of decline in AD, in the blinded data fast decliners and improvers were different at screening on verbal fluency, working memory, and complex information processing speed. Further analyses will focus on the smaller placebo group. These measures have potential use in strategic subject selection to fulfill the NINCDS-ADRDA requirement of supplementing theMMSE for confirming cognitive impairment, documenting progressivity (another NINCDS-ADRDA diagnostic criterion neglected in trials), and identifying improvers at screening for exclusion, and should be considered in protocol design.