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P1‐470: Validity study of the Montreal cognitive assessment in patients with vascular dementia
Author(s) -
Santana Isabel,
Freitas Sandra,
Simões Mário Rodrigues
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.752
Subject(s) - montreal cognitive assessment , cronbach's alpha , dementia , medicine , cognition , population , vascular dementia , mini–mental state examination , gerontology , psychology , cognitive impairment , clinical psychology , psychiatry , psychometrics , disease , environmental health
and explored by neuropsychological tests, brainMRI, and biological markers, we selected 109 subjects. These 109 subjects (33 A-MCI, 63 SCI and 13 NC) have been carefully examinated with neuropsychological memory tests (FCSR test, span, logical memory) and specific neuropsychological dysex ecutive tests:WisconsinCard Sorting Test (WCST), TrailMaking Test (TMT)A and B, verbal fluency, REY complex figure. Results: At SCI stage, we can observe some patients with dysex ecutive syndrome, without memory impairment (28 on 65 SCI 43%). Themost sensitive tests areWSCT-more precisely the number of cards (35.7%) -and verbal fluency test (35.7%), then WCST number of categories (21.4%) and REY complex copy (21.4%). AtMCI stage 11 A-MCI exhibit a dysex ecutive syndrome (33%). The most striking difference between A-MCI single domain (Non dysexecutive MCI) and A-MCI multiple domain (Dys-MCI) is REY copy. Finally the 28 SCI with dysex ecutive syndrome can be considered as dysex ecutive MCI (Dys-MCI).Conclusions: SCI is a transitional state wherememory complaint is purewith normal cognitive examination (especially episodic memory tests). However a careful examination, peculiarly of executive functions, shows that an important proportion of subjects (43%), exhibits a dysex ecutive syndrome (Brandt et al., 2009) . We can hypothesis that executive dysfunctioning could precede memory alteration in certain MCI. It raises the problem of classic topography of lesions at early stage of AD (Braack and Braack 1991).