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P1‐467: Genetic risk and cognitive performance in the Wisconsin registry for Alzheimer's prevention (WRAP)
Author(s) -
Sager Mark,
Koscik Rebecca,
Jonaitis Erin,
La Rue Asenath,
Hermann Bruce
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.749
Subject(s) - family history , apolipoprotein e , confidence interval , neuropsychological test , medicine , gerontology , cognition , boston naming test , demography , effects of sleep deprivation on cognitive performance , alzheimer's disease , psychology , neuropsychology , disease , psychiatry , sociology
an adaptation of the Boston naming test for South America (Allegri and cols, 1997). The same had been validated with information of the relatives or caregivers ofpatients. It presented limitations of loweducational degreeand lackof aging patients (> 75 years) in the sample.Our objectiveswere to study the normative data of the Argentina Version for the Boston Naming test in a dwelling extended population of normal subjects. To analyze the discriminative validity for detect disorders of the language in patients with Alzheimer disease. Methods: 210 normal adult subjects were selected between 20-93 years old of the data base Argencog (Program of Baremizaci on de Test Diagnoses in the Area of Neurociencias Mental). Were selected 356 patients with probably Alzheimer disease (AD) and with vascular disease. Then was administered a test of language based on pictures that score in a range from 0 to 60. The sample was divided considering the age in 4 groups: < 55 (G1), 56-65 (G2), 66-75 (G3) y > 75 (G4). The groups were matched by age, education, and Beck Inventory. In addition, an analysis was performed according to educational degree (primary school, high school and university). Positive Predictive value (VPP) and negative (VPN) and positive likelihood ratio (LR+) were calculated. Also Areas under the curve (AUC) with the ROC method were obtained (Receiver Operator Characteristics). Results: In normal controls, were observed better performance in the Boston Naming Test with higher educational level (r 1⁄4 0.43; p < 0.001) and less results in aging subjects (r1⁄4 0.50; p< 0.001). Differences between groups were confirmed with the ANOVA test. Better Cut off point were calculated for all the groups with AD; CDR mean 1.17 (0.62). Patients G2: AUC 0.97, cut off point 45 (sensitivity 96.2%; specificity 90.9%, LR+10.58). Patients G3:0.97, cut off point 47 (sensitivity 96.6%; specificity 90.9; LR+10.62). Patients G4: AUC 0.93, cut off point 40 (sensitivity 84.2%; specificity 87.5%; LR+6.73). Conclusions: Normative data for a South American version of the Boston Naming Test show an excellent discriminative validity. It present as a useful diagnostic test for detection disorders of the language in AD. Losing sensitivity and specificity in elderly patients.