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P1‐455: CERAD memory composite score is an accurate neuropsychological predictor of progression to Alzheimer's disease: AddNeuroMed study
Author(s) -
Paajanen Teemu,
Hanninen Tuomo,
Tunnard Catherine,
Hallikainen Merja,
Mecocci Patrizia,
Sobow Tomasz,
Tsolaki Magda,
Vellas Bruno,
Lovestone Simon,
Soininen Hilkka
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.737
Subject(s) - neuropsychology , receiver operating characteristic , neuropsychological assessment , cognitive impairment , alzheimer's disease , cognition , neuropsychological test , medicine , disease , psychology , biomarker , audiology , gerontology , psychiatry , biochemistry , chemistry
test scores were as follows: SMMSE 11-30, NPI 0-57, CDT 0-14, ZBI 1-40, Katz’s ADL 0-6 and Lawton’s IADL 9-27. MMSE was better correlated to Lawton’s IADL (directly), and also to the NPI (inversely) and to the ZBI (inversely). CDR showed good (inverse) correlations to the MMSE and to the SMMSE scores, and also to the CDT, to Lawton’s IADL and to Katz’s ADL. All other comparisons among these scales resulted in statistical differences in regard to their respective scores. Conclusions: In this sample of patients with low average schooling, the MMSE had a better correlation with functional independence tests and with caregiver burden. Scales may be differentially sensitive according to the objective of the evaluation.