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P1‐442: Determining rate of decline in pre‐Alzheimer's and Alzheimer's Disease AIBL participants using a regular brief cognitive assessment
Author(s) -
Maruff Paul,
Ellis Kathryn,
Harrington Karra,
Gale Joanne,
Fredrickson Amy,
Darby David,
Masters Colin
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.724
Subject(s) - cognitive decline , neuropsychology , cognition , psychology , gerontology , dementia , neuropsychological test , alzheimer's disease , audiology , medicine , disease , psychiatry
Background: The dorsolateral prefrontal circuit of the basal ganglia is related to executive functioning, as the motor circuit is related to motor activity. Both have structures and neurotransmitters in common, which favors the hypothesis of an association between executive performance and motor control. The objectives was to investigate possible correlations between performance in executive and motor tests in an elderly cohort. Methods:We conducted a community-based study of cognitive and neuropsychiatric disorders in Caet e, a small town in southeast Brazil. A total of 639 participants (75+ years) completed the clinical evaluations from the study protocol; preliminary data from 114 individuals were analyzed. Cognitive status was ascertained through an expert consensus panel. Participants were classified as without cognitive impairment (controls), cognitive impairment no dementia (CIND), and dementia subjects. The UPDRS motor scale and a phonemic verbal fluency test (FAS) were administered to all subjects. Spearman’s correlations were calculated to measure the level of association between cognitive and motor scores. Results: The sample was composed of 77 subjects (47 women, aged 80.23 6 4.04 years and with 2.98 6 2.83 years of education), being 28 controls, 26 cases with CIND and 23 with dementia. A significant correlation was found between FAS and UPDRS scores only among controls (rho 1⁄4 0.519, p 1⁄4 0.005). Conclusions: Performance in an executive function test was found to be associated to motor control only in cognitively healthy individuals. It is possible that patients’ groups suffered influence from other factors related to cognitive and functional decline. P1-442 DETERMINING RATE OF DECLINE IN PREALZHEIMER’S AND ALZHEIMER’S DISEASE AIBL PARTICIPANTS USING A REGULAR BRIEF COGNITIVE ASSESSMENT Paul Maruff, Kathryn Ellis, Karra Harrington, Joanne Gale, Amy Fredrickson, David Darby, Colin Masters, CogState Ltd, Melbourne, Australia; 2 Mental Health Research Institute of Victoria, Kew, Australia; The Mental Health Research Institute of Victoria, Melbourne, Australia; University of Melbourne, Melbourne, Australia.