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P1‐410: Neocortical disconnectivity disrupts semantic binding in Alzheimer's disease
Author(s) -
Festa Elena,
Ott Brian,
Tremont Geoffrey,
Heindel William
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.691
Subject(s) - perception , psychology , crossmodal , object (grammar) , task (project management) , semantic memory , set (abstract data type) , cognitive psychology , sensory system , synesthesia , communication , visual perception , cognition , neuroscience , computer science , artificial intelligence , management , economics , programming language
they would choose to visit a number of designated locations. Individuals paths can only be used once, starting and end point are also fixed. In the second, low demand condition, subjects are instructed to simply follow instruction to achieve an error-free performance. Results: Statistical analysis (ANOVA) showed that there are significant differences among three groups in version 1 (F 1⁄4 23.22; p < 0.000), version 2 (F 1⁄4 35.96; p < 0.000), profile (F 1⁄4 33.94; p < 0.000). In all cases AD group showed poorer performance than MCI group, and this one poorer performance than NA group. A qualitative analysis showed those significant differences among three groups in mistakes made but not in planning time or total time. Conclusions: Planning abilities show a continuum decline among NA, MCI and AD. These difficulties are related with strategies used and error learning abilities. A planning measure could be necessary included in early neuropsychological assessment.