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P1‐407: Comparison of multiple neuropsychological models to predict amyloid deposition
Author(s) -
England Rebecca,
Becker J. Alex,
Olson Lauren,
Frishe Katherine,
Frey Meghan,
Maye Jacqueline,
Johnson Keith,
Sperling Reisa,
Rentz Dorene
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.688
Subject(s) - logistic regression , neuropsychology , stepwise regression , psychology , confidence interval , neuropsychological test , regression analysis , medicine , cognition , statistics , psychiatry , mathematics
aforementioned computerized visuo-perceptual task battery and the CDR System, an automated cognitive battery assessing aspects of psychomotor/ information processing speed, attention and memory were assessed at baseline, week 12 and week 24. Psychometric properties (test-retest, concurrent validity, inter-correlation of component scores for composite measures and sensitivity to change) were explored. Results: Visuo-perceptual test measures demonstrated good to fair psychometric properties and were most strongly correlated with measures of psychomotor/ information processing speed and attention. However, some patients performed at ceiling on the tasks. A small effect size improvement (0.44) was seen on a measure of ‘object form perception’, following 24 weeks treatment with galantamine. Conclusions:Development and validation of test batteries which are able to assess specific domains of cognition and in particular aspects of visuospatial ability, attention and executive function, will be important in the definitive assessment of efficacy in future clinical trials in DLB patients and also in the related condition PDD. Issues of inter-correlated cognitive measures and differences in task difficulty not related directly to the cognitive domain assessed will be discussed, as these may present challenges in the profiling of cognitive impairment across multiple domains.