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P1‐386: Predicting brain amyloid‐β burden with atrophy in MCI
Author(s) -
Tosun Duygu,
Schuff Norbert,
Weiner Michael
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.667
Subject(s) - precuneus , atrophy , neuroimaging , pittsburgh compound b , voxel based morphometry , voxel , neuroscience , magnetic resonance imaging , medicine , psychology , pathology , radiology , cognition , cognitive impairment , white matter
between controls and the PSEN1Pre200 or APP cohort. Only one APP subject had a mutation within the amyloid-ß coding domain (A692G, Flemish). His total ARWMC score (14) was disproportionately higher than the median score for the APP group (0), the remainder of which had mutations at positions 717 and 719.Conclusions: The PSEN1Post200 mutation group in this study had a later age at onset andmore severewhite matter “burden” onMRI than the PSEN1Pre200 group. These increased, predominantly parieto-occipital, white matter changes probably reflect vascular pathology, most likely amyloid angiopathy given the subjects’ young age and lack of comorbidities. Study of the differential influence of FADmutations can inform our understanding of the pathophysiology of AD with potentially important implications for therapeutic trials.