Premium
P1‐383: Assessing the impact of APOE genotype on regional brain volume
Author(s) -
McGeown William,
Biundo Roberta,
Shanks Michael,
Venneri Annalena
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.664
Subject(s) - neocortex , precuneus , atrophy , grey matter , asymptomatic carrier , brain size , voxel based morphometry , apolipoprotein e , psychology , hippocampus , posterior cingulate , cortex (anatomy) , neuroscience , medicine , cognition , white matter , disease , magnetic resonance imaging , radiology
of their parents after the age of 63. Of these, 45 (age 72 6 8) reported they were FH+ and 43 (age 776 8) were FH-. Within the FH+ group, 28 subjects were mFH+, 13 were pFH+, and 4 reported dementia in both parents (mpFH+). We evaluated our hypotheses in 12 regions-of-interest (ROI), covarying age and APOE carrier status. Results: Within the CDR0 group, mFH+ subjects had greater PIB retention in frontal ROIs (p< .05) compared to FH-. These results persisted (p < .05) after APOEe4 carrier status was added to the model. Within the CDR0.5 group, mFH+ subjects had greater PIB retention in global, frontal, precuneus, lateral temporal, parietal (all p < .0001), occipital (p< .05) and parahippocampus (p< .05) ROIs compared to FH-. When APOEe4 carrier status was added to the model, results persisted (p< .05) in frontal, precuneus, and parietal ROIs. CDR0.5 mFH+ subjects displayed decreased FDG in lateral temporal, medial temporal, hippocampus, parahippocampus, parietal, and occipital (p < .05) relative to CDR0.5 FHsubjects. This effect persisted fully in hippocampus (p < .05) and marginally significantly (p1⁄4 .0725) in medial temporal after inclusion of APOEe4 carrier status in the model. Conclusions: Self-reported parental history of dementia is associated with increased amyloid deposition in both CDR0 and CDR0.5 subjects, and is also associated with reduced brain glucose metabolism in CDR0.5, but not CDR0, subjects. These results are independent of APOE status. These findings are consistent with the hypotheses that amyloid deposition occurs prior to any clinical symptoms, and that family history is a significant risk factor for the development of AD pathology.