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P1‐357: FreeSurfer in regional analysis of beta‐amyloid deposition with [11C]PIB positron emission tomography
Author(s) -
Su Yi,
Vlassenko Andrei,
Benzinger Tammie,
D'Angelo Gina,
Blazey Tyler,
Vora Shivangi,
Morris John,
Mintun Mark
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.637
Subject(s) - positron emission tomography , white matter , precuneus , nuclear medicine , segmentation , magnetic resonance imaging , artificial intelligence , medicine , neuroscience , psychology , computer science , radiology , functional magnetic resonance imaging
network. This finding may reflect the fact that PiBdo have slower rates of Aß accumulation, or that they are less numerous to show a significant PiB accumulation. Arguing for the later hypothesis, the distribution of individual rates of neocortical Aß accumulation revealed to be bimodal, and clustering analyses led to a consistent threshold to separate these two subgroups into “PiB non-accumulators” vs. “PiB accumulators”. The voxelwise 3-way ANCOVAwas then re-computed with the “PiB accumulators” only and the results were almost unchanged (see Figure). Conclusions: This study highlighted that rates of Aß accumulation increased as the PiB load increased. It thus suggests that Aß deposition does not reach a plateau when cognitive decline occurs but is instead an on-going mechanism over the course of AD. Besides, this is the first study to take into account the fact that Aß accumulation may not increase in all individuals which might offer the possibility to identify the earliest stages of brain Aß accumulation in PiBaccumulators subjects.