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P1‐346: Acceleration of brain atrophy rates with advancing cognitive deterioration from normal aging to MCI to Alzheimer's disease
Author(s) -
Schuff Norbert,
Insel Philip,
Chiang Gloria,
Truran Diana,
Gamst Anthony,
Jack Clifford,
Aisen Paul,
Petersen Ronald,
Shaw Leslie,
Trojanowski John,
Weiner Michael
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.626
Subject(s) - atrophy , entorhinal cortex , inflection point , cognition , cognitive decline , psychology , neuroscience , hippocampus , cardiology , dementia , medicine , disease , mathematics , geometry
quences using Fazekas’ subcortical and periventricular scores, the Age-Related White Matter Changes Rating Scale (ARWMC) and the Cholinergic Pathways Hyperintensities scale (CHIPS). A CHIPS analogy for CMBs was also provided (the Cholinergic Pathways Microbleeds scale-CHMBS). Lacuna infarctions are counted on FLAIR images. Normalized inter-caudate (ICD) and inter-uncal distance (IUD) were calculated on T1. Besides MiniMental State Examination and geriatric depression scale, detailed neuropsychological tests were administered to assess various cognitive domains including attention (digit span forward and backwards, trial making A), executive functions (Trial making B, verbal fluency), language (Boston naming test, verbal fluency), visuospatial abilities (clock drawing test, line orientation test, Benton’s face recognition), and memory (Rey’s auditory verbal learning test, enhanced cued recall, category fluency, Weshler memory scalevisual memory test). Results: CMBs burden was not related to cognitive function or dysfunction (p>0.05). Irrespective to the severity of cerebral atrophy, WMHs load along with lacunae had more significant effects on cognitive functions in comparison with CMBs burden. Conclusions: Distinct topographical distribution of CMBs and WMHs in relation to cholinergic pathways seems to be important in affecting cognition.