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P1‐343: Tracking progression with serial MRI in the language variants of frontotemporal lobar degeneration
Author(s) -
Rohrer Jonathan,
Clarkson Matt,
Kittus Raivo,
Rossor Martin,
Ourselin Sebastien,
Warren Jason,
Fox Nick
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.623
Subject(s) - frontotemporal lobar degeneration , atrophy , primary progressive aphasia , temporal lobe , semantic dementia , frontotemporal dementia , medicine , lateralization of brain function , dementia , frontal lobe , psychology , pathology , audiology , neuroscience , disease , epilepsy
progression within 2 years.Methods: 87 participants had repeated structural 1.5T MRI scans, clinical visits, and psychometric testing for at least 2 years. MRI scans were processed using voxel-based morphometry (VBM; SPM5) and automated parcellation (Freesurfer). Baseline and 2-year values for selected regions of interest (ROIs) were extracted and annual percent change (APC; over 2 years) was calculated as previously described. Change in psychometric performance was also calculated (Table 1).7 diagnostic groups were defined by baseline diagnosis and conversion status over 2 years as follows: stable AD (n 1⁄4 4), MCI to AD converters (MCI-C, n 1⁄4 5), stable MCI (MCI-S, n 1⁄4 24), CC to MCI converters (CC-C, n 1⁄4 3), stable CC (CC-S, n 1⁄4 21), HC to CC converters (HC-C, n 1⁄4 1), and stable HC (HC-S, n 1⁄4 29). Baseline and APC values, demographic variables, and psychometric performance were compared between groups. Effect sizes (d) for selected measures were calculated for converter vs. stable patient groups. Results: Baseline and APC inMTLmeasures were significantly different between groups (Fig. 1A), with patients demonstrating more baseline atrophy and faster annual atrophy rates than HC-Ss. Additionally, converters showed greater baseline atrophy and APC over 2 years than stables. Baseline MTL measures and atrophy rates showed the largest effect sizes (Fig. 1B).Conclusions: Patients with mild AD and MCI and CC participants demonstrated increased atrophy rates relative to stable controls. Participants who declined clinically over 2 years showed more pronounced neurodegeneration at baseline and faster rate of atrophy than those who were stable, regardless of diagnostic group. Overall, MRI biomarkers are sensitive to neurodegeneration in early clinical stages.[1] Risacher et al.Neurobiology of Aging, 2010.; [2] Saykin et al. Neurology, 2006.