Premium
P1‐308: New MRI markers for Alzheimer's disease: a meta‐analysis of diffusion tensor imaging and a comparison with medial temporal lobe measurements
Author(s) -
Clerx Lies,
Visser Pieter Jelle,
Verhey Frans R.J.,
Aalten Pauline
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.587
Subject(s) - fractional anisotropy , temporal lobe , atrophy , diffusion mri , corpus callosum , entorhinal cortex , splenium , medicine , parahippocampal gyrus , alzheimer's disease , hippocampus , magnetic resonance imaging , pathology , psychology , cardiology , neuroscience , radiology , disease , epilepsy
cognitively normal (CN), mild cognitive impairment (MCI) and Alzheimer’s disease (AD). The purpose of this study is to investigate the change of PIB retention after one-year follow up in CN old individuals and patients with MCI and AD. Methods: 22 CN, 19 MCI, and 19 mild AD subjects were included. For each group, the proportion of apolipoprotein e4 positive cases was approximately 50% for each of the three groups. All subjects underwent clinical assessments and PIB PET at two time points, approximately one year apart. PIB retention was quantified in regional cortical to cerebellar ratio units.Results: In CN, PIB retention at one-year follow up increased significantly compared with baseline value in the diffuse brain regions including the frontal, lateral temporal, medial temporal, lateral parietal, posterior cingulate-precuneus (PC-PRC), and occipital cortices, and basal ganglia. In contrast, such longitudinal increase of regional PIB retention was observed only in the lateral parietal and PC-PRC for MCI, and only in the PC-PRC for AD. Conclusions: The results of this study indicate that the regional pattern of longitudinal PIB retention change is different across the spectrum of cognitive ability. PIB retention seems to be already saturated in diffuse cortical regions in MCI and early clinical AD.