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P1‐256: Ribosomal Genes Activity, Apolipoprotein‐E and Interleukin‐6 Polymorphisms in Alzheimer's Disease
Author(s) -
Rasmussen Lucas,
Labio Roger,
Chen Elizabeth,
Minett Thais,
Bertolucci Paulo,
Smith Marilia,
Payão Spencer
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.536
Subject(s) - apolipoprotein e , allele , genotype , genotyping , disease , medicine , restriction fragment length polymorphism , biology , single nucleotide polymorphism , genetics , gastroenterology , gene
plasma drug level (2.5 hours). The study design had two independent variables: TOMM40 gene (short vs long; between-subjects) and drug administration (placebo vs 0.5 mg vs 1 mg; within-subjects). We measured the difference from baseline in total recall. Results: We conducted a 2 X 3 repeated-measures ANOVA and observed an interaction between drug administration and TOMM40 (p 1⁄4 .022). Pairwise comparisons indicated that poly-T length did not influence memory performance when placebowas administered, but was associated with worse recall when lorazepam was administered, both for 0.5 mg (p 1⁄4 .004) and 1.0 mg (p 1⁄4 .001) doses. Conclusions: Our pilot data suggest that variants of TOMM40 may serve as pharmacodynamic predictors of drug-induced memory dysfunction in e4 negative individuals, most of whom had the e3/e3 genotype. Given that the frequency of e3/e3 in the general population is over 55%, this biomarker could have important clinical implications.