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P1‐241: Impact of APOE Genotype Disclosure on Exercise and Mental Activities
Author(s) -
Klopfenstein Erin,
Chen Clara,
Christensen Kurt,
Lautenbach Denise,
Cupples L. Adrienne,
Roberts Scott,
Green Robert
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.521
Subject(s) - logistic regression , apolipoprotein e , medicine , disease , ethnic group , psychology , randomized controlled trial , family history , clinical psychology , physical therapy , gerontology , sociology , anthropology
set of AD did not differ by the e4 allele carrier status (10.2 years in the e4positive group, 9.1 years in the e4-negative group). There were no differences between e4-positive and e4-negative group in age at baseline, sex, education, age at onset, duration of AD, severity of dementia. Significant factors that affects mortality during the follow-up included age at baseline and age at onset. Adjusting for age at baseline and age at onset, the presence of an e4 allele did not show increased risk of mortality (RR 1⁄4 0.98, 95% CI 1⁄4 0.64-1.49) and the risk of effect of the e4 allele not vary by age, sex, education in this sample. Conclusions: This study provide the first information about the effect of the e4 allele on mortality in oriental elderly with AD. The APOE e4 allele was not associated with mortality in patients with AD.