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P1‐228: Genetic Risk Factors for AD Biomarkers
Author(s) -
EliasSonnenschein Lyzel,
Verhey Frans R.J.,
Kehoe Patrick,
Graff Caroline,
Kenis Gunter
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.508
Subject(s) - single nucleotide polymorphism , apolipoprotein e , atrophy , medicine , alzheimer's disease neuroimaging initiative , pathophysiology , cerebrospinal fluid , oncology , dementia , disease , bioinformatics , biology , genotype , genetics , gene
length>30), resulting in six TOMM40 genotypes (S/S, S/L, S/VL, L/L, L/ VL, VL/VL). Chi-square or Fisher’s exact tests examined the independence of pairs of race and risk variables overall and subsequently by APOE e 4 carrier status (alpha 1⁄4 .05). Results: Race was significantly associated with TOMM40 genotype (p < .0001), but not FH (p 1⁄4 .44) or APOE (p 1⁄4 .14) in the whole sample. Among e4 carriers, race and TOMM40 were not independent (p< .0001); in this higher APOE risk subset, 51% of Caucasians had both TOMM40 alleles in the higher risk L and VL lengths compared to 11% of African Americans. Among none4carriers, race and TOMM40were also related (p1⁄4 .002); 26% of Caucasians had both TOMM40 alleles in L or VL compared to 6% of African Americans. Conclusions: Given higher risk of LOAD and lower prevalence of supposed “high risk” TOMM40 lengths in our African American sample, we conclude that the effect of TOMM40 on LOAD risk is likely to vary by race. Further research is needed to understand how TOMM40 and other risk factors interact to produce AD in diverse populations.