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P1‐181: Subjective Memory Complaints and Cognitive Tests in the Australian Imaging Biomarkers and Lifestyle Flagship Study of Ageing (AIBL)
Author(s) -
Zhang Ping,
Rowe Christopher,
Ellis Kathryn,
Masters Colin,
Martins Ralph N.W.,
Ames David,
Macaulay Lance,
Szoeke Cassandra
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.461
Subject(s) - depression (economics) , cognition , psychology , anxiety , prodrome , population , cognitive decline , dementia , gerontology , medicine , disease , psychiatry , environmental health , psychosis , economics , macroeconomics
activities of daily living (IADL). The aim of this study was to investigate the differences of ADL and IADL according to the severity of WM changes in a large, well-defined cohort of patients with amnestic mild cognitive impairment (aMCI). Methods: A total of 1514 aMCI patients were divided into three groups (1026 mild, 393 moderate, and 95 severe) depending on the degree of WM changes as indicated on brain MRIs. We compared total ADL/IADL scores and analyzed prevalence of each item among 3 groups. Results: While Barthel ADL scores demonstrated no differences among 3 groups, the severity of WM changes were associated with greater age, hypertension, higher Hachinski Ischemic score, pronounced impairment of IADL. Among Seoul IADL items, it showed more frequent impairment in ‘using transportation’, ‘grooming’ and ‘leisure/hobbies’ according to the degree of WM changes. Conclusions: The more severe WM changes are seen on MRI, the more frequent impairments of IADL are observed. The severe WM changes are associated with higher impairment on ‘using transportation, ’grooming’ and ‘leisure/hobbies’.