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P1‐160: Clinical phenotypic variability in an Italian family bearing the IVS6+5_8delGTGA mutation in PGRN gene
Author(s) -
Marcon Gabriella,
Tagliavini Fabrizio,
Rossi Giacomina,
Giaccone Giorgio,
Grisoli Marina,
Piccoli Elena,
Geatti Onelio,
Zanini Sergio
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.440
Subject(s) - frontotemporal dementia , dementia , disease , mutation , genetics , phenotype , frontotemporal lobar degeneration , family history , neuropsychology , medicine , gene , psychology , biology , psychiatry , pathology , cognition
inverse correlation. As less was cognitive impairment and memory deficit as higher were scores in depression Scales, and as more profound was dementia, patients were less depressed. 33 patients were “naive”, 18 patients had previous uneffective treatment with so-called neuroprotectors and vitamins. 6 patients were treated with MAO inhibitor (amitriptyline) but discontinue their treatment because of memory detoriation and worsening of the activities of daily living. 16 patients with MCI successfully overcome their depressive episode when started effective treatment for their memory impairment.Conclusions: Both depression and dementia are existing co-morbidities especially in elderly, and need in-time and precise evaluation. Early and correct diagnosis of both conditions must serve as basis for further effective management. In MCI effective treatment ofmemory impairment could be paramount for general improvement of the mood and reducing of the stress, treatment of patients with Dementia with MAO is usually complicated because of drowsiness and additional reduction of daily activities. Every patients with dementia must be evaluated for depression and treat accordingly the neurological and cognitive deficit.