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P1‐157: The AD8 informant interview: Influence of cultural bias on reliability and diagnostic performance in early cognitive impairment (ECI)
Author(s) -
Lim Wee Shiong,
Chong Mei Sian,
Mark Chan Peng Chew,
Tay Laura
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.437
Subject(s) - cronbach's alpha , reliability (semiconductor) , dementia , psychology , ethnic group , factor analysis , clinical psychology , developmental psychology , psychometrics , medicine , statistics , power (physics) , physics , mathematics , disease , pathology , quantum mechanics , sociology , anthropology
a posterior-anterior gradient of loss by visit 2, with early changes in inferior temporal and superior parietal regions spreading later to affect the inferior parietal and occipital lobes. A mean of the annual whole brain atrophy rates across the study was 0.94% (normal age matched atrophy rate 1⁄4 0.32%). Based on the young age of onset, progressive visual dysfunction and neuroimaging evidence of occipito-parieto-temporal atrophy, a diagnosis of PCA attributable to probable AD was made. Conclusions: The present case represents a unique opportunity to study the clinical and neuropsychological emergence of PCA. PCA may have a very focal onset but subtle cognitive complaints and structural losses may precede even MCI criteria by some years. Serial neuroimaging and neuropsychological assessment may aid allow earlier diagnosis when disease modifying treatments may be more effective.