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P1‐103: Development of highly accurate measurements of Aβ using formic acid
Author(s) -
Nanjo Toshifumi,
Tooyama Ikuo,
Kameshima Naoko,
Fukuhara Takaomi,
Koge Masahiro
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.382
Subject(s) - formic acid , neutralization , monomer , chemistry , sample (material) , chromatography , sample preparation , analytical chemistry (journal) , organic chemistry , medicine , polymer , antibody , immunology
AG volumes from subjects in the Italian Brain Normative Archive (Galluzzi et al., 2009). Methods: We included data on manual segmentation of 422 HC and 228 AG from 422 subjects in the Archive aged 20 to 84 years. We conducted correlation analysis, hierarchical regression and ANOVA to determine interaction effects. Results: Interactions: There was no significant difference in age between men and women (p1⁄4 0.4094) and no interaction between sex and hemisphere on HC/AG volumes (hemisphere: HC p < .0001; AG p 1⁄40.011 / sex: HC p< .0001; AG p1⁄40.0098). OnlyAG volumes for women when both hemispheres were considered and right AG volumes when all genders were considered have a negative correlation with Age. When sex was considered as confounding variable in hierarchical regression, age was linearly associated only with right AG volumes (Bêta 1⁄4 3.365; p 1⁄4 0.0078). Age and Age have no significant effects on HC/AG volumes (p > 0.280 for both HC and AG) in a quadratic regression model. Yet, if sex was introduced as an independent variable in the above models, age kept a weak effect on rightAG volumes (Bêta1⁄4 3.438; p1⁄4 0.0960). Normative data:When the subjects were divided by decade into six different strata ,the difference between age groups was significant only for right AG volumes (p 1⁄4 0.0212). ATucky multiple comparison test showed that there was no significant difference in HC volumes between any strata. The distribution of HC/AG volumes showed homogeneity of volumes for HC but not for AG throughout all groups. Conclusions: Except for the rightAG, this study demonstrates that age has no discernable effects on HC/AG volumes and that there exists as wide a variability in early adulthood as in later years. The volumes from the Archive can be used as normative data for future research and clinical studies.