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P1‐096: Effect of CSF collection procedures via cisterna magna catheter or lumbar puncture at different frequencies on Alzheimer's biomarker levels in cynomolgus monkeys
Author(s) -
Li Jinhe,
Waring Jeffrey,
Ellis Teresa,
LeBlond David,
Villa Flordeliza,
Hutcheson Daniel
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.375
Subject(s) - cisterna magna , biomarker , medicine , cerebrospinal fluid , lumbar puncture , clinical trial , lumbar , surgery , biology , biochemistry
nitive decline (fast vs. slow cognitive decline: mean6SD: 1051.16178.7 vs. 1237.96274.2 pg/ml; p1⁄4 0.037) and show a significant correlation with the rate of cognitive decline during 1 year follow-up (r 1⁄4 0.315; p 1⁄4 0.048). Multivariate analysis revealed that SCF plasma levels (B 1⁄4 0.279; p 1⁄4 0.041), age (B 1⁄4 0.393; p 1⁄4 0.006) and MMSE scores (B 1⁄4 0.420;p 1⁄4 0.002) at baseline were independent predictors for the rate of cognitive decline. Conclusions: These results suggest that lower SCF plasma levels are associated with a higher rate of cognitive decline in AD patients. Thus, treatment strategies increasing SCF plasma levels could be useful for delaying the progression of AD. Further longitudinal studies are necessary to elucidate the kinetics and the potential role of plasma SCF as a surrogate marker of disease progression and treatment target in AD patients.