P1‐081: Retinal vascular parameters as biomarkers for Alzheimer's disease | Zendy

Frost Shaun | Zendy; Martins Ralph | Zendy; Bourgeat Pierrick | Zendy; Kanagasingam Yogesan | Zendy; Rowe Christopher | Zendy

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P1‐081: Retinal vascular parameters as biomarkers for Alzheimer's disease

Author(s) -

Frost Shaun,

Martins Ralph,

Bourgeat Pierrick,

Kanagasingam Yogesan,

Rowe Christopher

Publication year - 2011

Publication title -

alzheimer's and dementia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.713

H-Index - 118

eISSN - 1552-5279

pISSN - 1552-5260

DOI - 10.1016/j.jalz.2011.05.361

Subject(s) - retinal , confounding , neuroimaging , medicine , biomarker , cohort , disease , retina , ophthalmology , imaging biomarker , neuropsychology , cardiology , psychology , neuroscience , magnetic resonance imaging , radiology , cognition , psychiatry , biology , biochemistry

Results: Comparing AD and non -AD patients, total Tau had a sensitivity/ specificity of 89%/87%; ptau181: 85%/91%; Ab 1-42: 77%/74%;and IATI: 89%/80%. Optimum cut-offs were evaluated for total tau at 302 pg/mL, ptau 181: 65 pg/mL, Ab 1-42: 515 pg/mL, and IATI: 0.76. If both ptau 1⁄4 65 pg/mL and IATI< 0.80, sensitivity/specificity was 74%/98%. Conclusions: CSF biomarkers are helpful tools to support AD diagnosis in a memory clinical center. We report our local optimum cut-offs values to discriminate between AD and non-AD patients.

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