P1‐065: Are CSF biomarkers useful for the diagnosis of probable Dementia with lewy bodies?

(interquartile range (IQR):51.2-58.0), 40 (47.6%) women). The median MMSE at inclusion was 14.5 points (IQR:9-21). Thirty (36%) patients had hypertension, 35 (42%) dyslipidemia, 5 (6%) diabetes, 6 (7%) ischemic heart disease and 2 patients (2%) had a history of stroke. The median Fazekas total score was 1.0 (IQR:1.0-1.0). Using the Scheltens scale, the median for total PVH score was 3.0 (IQR:1.0-3.0), for total WMH score was 2.5 (IQR:1.0-5.0), for total BG scorewas 0.0 (IQR:0.0-0.0), and for total ITF score was 0.1 (IQR:0.0-0.0). Only two patients had no SH. Hypertension was significantly associated with the Fazekas score (p1⁄4 0.02) and with the total WMH Scheltens score (p 1⁄4 0.04). The median MTLA score was 2.0 (IQR:1.0-3.0) and its severity was correlated with a lower MMSE (p < ;0.0001). In a subgroup of 33 patients, one or more BMBs were present in 24%. There was no difference in demographic, imaging and neuropsychological variables between patients who suffered their first symptoms before or after the age of 55. Conclusions: In our cohort of early-onset AD patients, vascular risk factors and vascular lesions onMRIwere surprisingly frequent, as reported in late-onset cohorts.