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P1‐062: Cerebrospinal fluid and serum autoantibodies against neurocytoskeletal proteins in patients with Alzheimer's disease
Author(s) -
Bartos Ales,
Ripova Daniela,
Svarcova Jana,
Cechova Linda,
Fialova Lenka,
Malbohan Ivan
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.341
Subject(s) - autoantibody , cerebrospinal fluid , antibody , antigen , medicine , immunology , neurofilament , neurodegeneration , endocrinology , immune system , disease , immunohistochemistry
states. The optimalprocess of clinical assessmentmay includemultiple technologies such as neuropsychological assessment, neuroimaging, and fluid biomarker analysis, each used at appropriate time points in a staged diagnostic pathway. EDAR is a Europe-wide prospective longitudinal study assessing the potential for CSF and other biomarkers, including cognition, in the early diagnosis of AD. Methods: Patients with mild cognitive impairment, AD and other dementias and healthy elderly controls (total n 1⁄4 144) were recruited from seven centres across Europe. Memory, attention and executive functions were assessed using the Cambridge Neuropsychological Test Battery (CANTAB). Cerebrospinal fluid was obtained on a single occasion and assayed using Luminex for As1-42, total tau and hyperphosphorylated tau. Results: Lower CSF As1-42 levels were associated with poorer performance on CANTAB paired associates learning (rho1⁄4 -.3, p< .001) and spatial working memory (rho1⁄4-.3, p1⁄4 .002) tests, andwith slower (rho1⁄4-.3, p1⁄4 .001) andmore variable (rho1⁄4-.4, p< .001) choice reaction time. The tau:As1-42 ratiowas lower in individuals with better episodic memory and less variable choice reaction time (both rho 1⁄4 .2, p 1⁄4 .01). High P-tau181P levels were associated with faster simple reaction time (rho 1⁄4 -.3, p 1⁄4 .001). CSF biomarker levels appeared unrelated to scores on tests of semantic memory and executive function. Associations between cognitive and CSF biomarkers differed between diagnostic groups. Conclusions: Among healthy and impaired elderly individuals, scores on computerised cognitive tests are correlated with CSF biomarkers of amyloid and tau pathologies.