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P1‐043: Peripheral and central responses of kynurenine pathway in response to low and high tryptophan‐containing food in rhesus macaques
Author(s) -
McCampbell Alexander,
Michener Maria,
Smith Brad,
Lennox Christina,
Dancho Mandy,
Yeh Suzie,
Zhang Rena,
Rajapaske Hemaka,
Ray William,
Reynolds Ian,
Kornilova Anna
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.323
Subject(s) - kynurenic acid , kynurenine , kynurenine pathway , ingestion , metabolite , tryptophan , medicine , endocrinology , chemistry , baboon , biology , biochemistry , amino acid
50% vs. 50%). The levels of tau phosphorylation on p-S396-S404 displayed an approximately 2-fold increase in “low-dose”, and 4-fold increase in “high-dose” sevoflurane anesthetized mice. The level of tau phosphorylation on pT181 also increased. The total tau levels did not change. The results of the 2-D electrophoresis shows a shift of the total tau protein from the basic ph range, into the most acid ph range in high-dose anesthetized mice, comparedwith controlmice.Conclusions: In this study, repeated sevoflurane anesthetized mice have both persistent hippocampal tau hyperphosphorylation and impairment in spatial memory. These findings provide a link between anesthesia and POCD, especially by 65 yr older patients, who have physiologically asymptomatic neurofibrillary lesions in hippocampus.