P1‐021: The changes of learning and memory abilities and insulin signal pathway on hippocampal neurons of diabetic mice | Zendy

Wang Rong | Zendy; Yao Jie | Zendy; Sheng Shuli | Zendy

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P1‐021: The changes of learning and memory abilities and insulin signal pathway on hippocampal neurons of diabetic mice

Author(s) -

Wang Rong,

Yao Jie,

Sheng Shuli

Publication year - 2011

Publication title -

alzheimer's and dementia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.713

H-Index - 118

eISSN - 1552-5279

pISSN - 1552-5260

DOI - 10.1016/j.jalz.2011.05.301

Subject(s) - morris water navigation task , creb , streptozotocin , hippocampal formation , hippocampus , intraperitoneal injection , immunohistochemistry , endocrinology , medicine , apoptosis , water maze , pi3k/akt/mtor pathway , insulin , western blot , insulin receptor , diabetes mellitus , chemistry , insulin resistance , biochemistry , transcription factor , gene

Structural vascular abnormality was observed in cortical branch of cerebral arteries in KK-A mice. Leakage of EB dye was markedly increased in KKA mice compared with C57BL/6J mice. Administration of telmisartan significantly decreased the EB extravasations. Co-treatment with GW9662 attenuated telmisartan-mediated protective effects of BBB in KK-A mice. Conclusions: These findings suggest that telmisartan has protective effects on cognitive decline in diabetic mice, partly due to prevention of BBB disruption via possible synergistic activation of PPAR-g as well as blockade of angiotensin II type 1 receptor signaling.

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