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P1‐001: The effects of angiotensin II and angiotensin 1‐7 in cognitive processes and oxidative stress in rats. Relevance for Alzheimer's disease
Author(s) -
Alin Ciobica,
Padurariu Manuela,
Hritcu Lucian,
Bild Veronica,
Bild Walther
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.281
Subject(s) - angiotensin ii , elevated plus maze , losartan , medicine , endocrinology , angiotensin ii receptor type 1 , renin–angiotensin system , psychology , chemistry , pharmacology , anxiety , blood pressure , psychiatry
(VROI). Hippocampal and dorsolateral frontal (DLFC) cortex VROIs were selected from the SPM sub-utility ‘Pickatlas’. In each subject, mean FDG uptake values within VROIs was computed using Mask subtool of SPM and normalized to the cerebellar uptake. Both in patients and controls, normalized VROI values were used as dependent variables in multiple regression analyses to search for metabolic correlations (connectivity) with the whole brain (uncorrected p < 0.001 at peak level and p < 0.05 FDR-corrected at cluster level). Correlation analysis was repeated in an independent group of 69 healthy subjects.Results:As compared to controls, pAD showed relative hypometabolism in precuneus, posterior cingulate gyrus and superior parietal lobule in both hemispheres. This hypometabolic area showed less metabolic connectivity in pAD with respect to CTR (autocorrelation versus wide correlation with temporal and frontal lobes, respectively). PAD showed limited correlation even innon-hypometabolic areas. Both hippocampi showed correlation with controlateral homologues only, while in CTR correlation was highlighted with precuneus/ posterior cingulate and frontal cortex. Similarly, DLFC correlation was limited to ipsilateral frontal cortex, while involving caudate nuclei and parietal cortex in CTR. Results in CTR were confirmed in the wider sample of 69 subjects. Conclusions: Metabolic connectivity is impaired in pAD. The reduced metabolic connections both in hypometabolic and non-hypometabolic areas suggest that metabolic disconnection (possible sign of degeneration at synaptic level) may antedates hypometabolism (early sign of neuronal death).