O3‐03‐04: Early intervention with docosahexanoic Acid (DHA) protects APOE4 acceleration of cognitive decline and plasma biomarkers in APOE4/5xFAD mice

healthy elderly (age > 65) in WHICAP, a community-based and ethnically diverse cohort in New York. The associations between plasma As40 and As42 levels and calorie-adjusted dietary intake of 10 nutrients [saturated fatty acid (SFA), mono-unsaturated fatty acid (MUFA), u-3 poly-unsaturated fatty acid (PUFA), u-6 PUFA, vitamin E, vitamin C, s-carotene, vitamin B12, folate, and vitamin D], selected due to their potential association with dementia risk, were examined using linear regression models, first unadjusted and then adjusted for age, gender, ethnicity, education, and s-amyloid assessment wave. Results: In an unadjusted model that simultaneously included all 10 nutrients, higher intake of u-3 PUFA was significantly associated with lower As40 (s 1⁄4 -25.9, p1⁄40.001) and lower As42 (s1⁄4 -11.9, p1⁄40.001) levels; higher intake of MUFAwas significantly associated with lower As40 (s 1⁄4 -1.6, p1⁄40.046) and As42 (s 1⁄4 -0.8, p1⁄40.023) levels. In an adjusted model, u-3 retained a strong association with lower plasma levels of As42 (s 1⁄4-13.6, p1⁄40.045) and As40 (s 1⁄4 -7.2, p1⁄40.021), while MUFAwas no longer associated with As. Other nutrients did not seem to be significantly associated with plasma levels of either As40 or As42. Conclusions: In cognitively healthy elders, higher dietary intake of u-3 PUFA is associated with lower plasma levels of both As40 and As42 (which are markers of slower cognitive decline and lower dementia risk inour cohort). Thus, plasma s-amyloid may be related to dietary habits.