Premium
F5‐01‐04: Brain Barrier: Alzheimer's disease and therapeutic options
Author(s) -
Begley David
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.2328
Subject(s) - paracellular transport , blood–brain barrier , transcellular , tight junction , microbiology and biotechnology , central nervous system , endothelial stem cell , barrier function , choroid plexus , cerebrospinal fluid , chemistry , biology , cell , biophysics , neuroscience , biochemistry , membrane , in vitro , permeability (electromagnetism)
yloid b peptides (Ab) showed a direct toxic effects on brain endothelial cells. Treatment with Ab caused morphological changes, and damaged barrier integrity, which was ameliorated by sulfated polysaccharide pentosan. Using real-time cell electric sensing, a protective effect of docosahexaenoic acid could be seen on Ab-treated brain endothelial cells. Conclusions: As a conclusion, studies on in vitro BBBmodels helped to reveal, that truncated tau and Ab damage brain endothelial cells by different pathways, and identified pentosan and docosahexaenoic acid as protective molecules for the BBB against AD-related pathological factors.