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P4‐258: Multi‐nutrient supplementation induces changes in synaptic protein expression
Author(s) -
Savelkoul Paul,
Merkes Mandy,
Kuipers Almar,
Hageman Robert,
Broersen Laus,
Kamphuis Patrick
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.2283
Subject(s) - synaptogenesis , neurite , synapse , microbiology and biotechnology , biology , gene expression , dendritic spine , biochemistry , neuroscience , gene , in vitro , hippocampal formation
Objectives: Alzheimer's disease (AD) is a progressive neurodegenerative disease and although its etiology is not yet completely known, it is clear that loss of dendritic spines and synaptic connections are a hallmark of AD. Preclinical work indicates that nutrients such as DHA, EPA, UMP, choline, B-vitamins, folate, phospholipids, vitamin C and E, and selenium (combined in FortasynTMConnect) can act as precursors or cofactors in the synthesis pathway of new neuronal membranes and act synergistically in synapse formation. To explore the molecular mechanisms in which these nutrient combinations stimulate synaptogenesis, we tested their effects on synaptic protein gene expression in vitro.