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P4‐195: Restoration of home cage activity in Tg2576 mice by immunotherapy with the Ab‐oligomer selective antibody A‐887755
Author(s) -
Relo Ana,
Barghorn Stefan,
Ebert Ulrich,
Hillen Heinz,
Gross Gerhard,
Schoemaker Hans,
Bespalov Anton
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.2218
Subject(s) - oligomer , hippocampal formation , genetically modified mouse , antibody , chemistry , hippocampus , alzheimer's disease , medicine , transgene , neuroscience , biochemistry , psychology , immunology , disease , organic chemistry , gene
endogenous neurogenesis occurs, we hypothesized that the neurotrophic factors may improve cognition by increasing endogenous neurogenesis. Therefore, to test this hypothesis, we assessed whether stem cell transplants improved cognition by increasing neurogenesis in the brain. Methods: To test this hypothesis, wild-type neural stem cells derived from Tg2576 X B6SJL/F1 mice were stereotactically injected into the brains of Tg2576 mice (15 mo), followed by BrdU injections. After one month, mice behavior was assessed using various tasks (Morris watermaze, novel object, novel odor task). Mice were subsequently sacrificed. We examined the effect of stem cells on pathology and neurogenesis using stereology. Results: Stem cell transplants in Tg2576 mice rescued cognitive deficits observed in these animals at 15 mo. as assessed with various behavioral tasks. The improvement in cognitive deficits was correlated with neurogenesis in the brain. Conclusions: Here we show that stem cell transplants in AD transgenic mice rescue the cognitive deficits and that this is associated with an increase in neurogenesis.