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P4‐130: Licofelone attenuates behavioral, neuroinflammatory and apoptotic alterations against animal models of Huntington's disease
Author(s) -
Bansal Puneet,
Kalonia Harikesh,
Kumar Anil
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.2152
Subject(s) - neuroprotection , proinflammatory cytokine , huntington's disease , pharmacology , superoxide dismutase , striatum , malondialdehyde , chemistry , neuroinflammation , antioxidant , endocrinology , medicine , biochemistry , inflammation , disease , dopamine
memory impairment was the most common presenting symptom in DLB (57%), followed by visual hallucinations (VH) (44%), depression (34%), problemsolving difficulties (33%), gait problems (28%) and tremor/stiffness (25%). In contrast, 99 % of AD carers reported impaired memory as the first symptom, whereas visual hallucinations were the presenting symtoms in only 3% of the AD cases. Prior to diagnosis, visual hallucinations (77%), gait/balance problems or falling (66%), tremor/stiffness (59%) and delirium/fluctuations of counsiousness (43%) were reported in DLB patients. There were no significant differences in symptom profile in the DLB subgroups according to dementia severity, age and gender. There was a trend towards REM-sleep behaviour disturbance (RBD) (p 1⁄4 0.071) and parkinsonism (p 1⁄4 0.157) being more common in male DLB patients, and RBD was numerically more common in the younger group (p < 0.094). Conclusions: Memory impairment and visual hallucinations were the most commonly reported presenting symptoms in DLB. The suggested sequence of symptoms in DLB patients, with cognitive and VH occuring before parkinsonism, suggest that cortical or forebrain changes often occur before involvement of the brain stem.