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P4‐112: Network efficiency changes in Alzheimer's diease and mild cognitive impairment
Author(s) -
Reid Andrew,
Evans Alan
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.2133
Subject(s) - cognitive impairment , neuroimaging , alzheimer's disease neuroimaging initiative , graph , cognition , computer science , psychology , artificial intelligence , pattern recognition (psychology) , neuroscience , theoretical computer science
metabolism. By contrast, the delta-score was not correlated to ß-amyloid within the pooled MCI1 and AD group, while it was related to cerebral metabolism in the temporal pole and orbito-frontal cortex within the patient groups (MCI1-AD and MCI2). Moreover, in MCI2 patients, the delta-score tended to decrease over the 18 months, and was significantly lower in converters than in non-converters. Conclusions: A hypothetical characterisation of the evolution of memory awareness in the course of AD is illustrated in the Fig.1. At a presymptomatic stage, our results outlined a progressive increase in subjective deficits with growing ß-amyloid burden. Then, at the MCI stage, with the progression of metabolic alterations, patients may start losing insight of their cognitive impairment. These results provide additional evidence (1) within the earliest stages, that subjective cognitive impairment could be a prodromal sign of MCI and AD, and (2) within the symptomatic stage, that anosognosia could be an early symptom characteristic of AD. (multimodal neuroimaging project on early Alzheimer’s disease)