Premium
P4‐109: Brain regions underlying distinct groups of “delusional ideas” (BEHAVE‐AD‐FW) in Alzheimer's Dementia: The osaki‐tajiri project
Author(s) -
Nakatsuka Masahiro,
Meguro Kenichi,
Tsuboi Masahiro,
Nakamura Kei,
Akanuma Kyoko,
Ouchi Yoshitaka,
Tanaka Naofumi,
Yamaguchi Satoshi
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.2130
Subject(s) - delusion , psychology , dementia , paranoia , neuroscience , abandonment (legal) , mini–mental state examination , cognition , audiology , psychiatry , clinical psychology , medicine , disease , cognitive impairment , political science , law
Results: PCA patients showed a clinical syndrome primarily characterized by visual object agnosia and prosopagnosia. Compared with controls, they had significantly higher MD, ParD and TraD and lower FA in the left ILF and IFOF. In addition, the right ILF had significantly higher MD and TraD and lower FA, the right IFOF had higher MD and TraD, and the CC higher MD. The fronto-parietal SLF, arcuate fasciculus, and CST were spared bilaterally. PCA patients also had GM atrophy in posterior temporal, inferior parietal and occipital regions bilaterally, and WM atrophy in the ventral occipito-temporal region, bilaterally. Conclusions: PCA patients in the present series harbor a prevalent damage to the ventral WM pathways of both hemispheres, with relative sparing of dorsal fronto-parietal connections. These results contribute to the definition of a more complete picture of the anatomical changes that occur in PCA in term of involved pathologic networks, and shed light onto the cognitive deficits and the different phenotypes of the syndrome.