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P4‐098: White matter integrity and intraindividual variability in aging and early‐stage Alzheimer disease
Author(s) -
Head Denise,
Jackson Jonathan,
Balota David,
Duchek Janet
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.2119
Subject(s) - precuneus , white matter , working memory , psychology , posterior cingulate , dorsolateral prefrontal cortex , hyperintensity , audiology , effects of sleep deprivation on cognitive performance , neuroscience , prefrontal cortex , cognition , medicine , magnetic resonance imaging , radiology
cognitive function (MMSE). Conclusions: The association between 5-HT4 receptor binding in amygdala and depressive symptoms suggests a coupling between serotonergic dysfunction and affective symptoms in early AD. However, the small sample size requires that these asscociations are corroborated in larger samples with more elaborate evaluation of emotional symptoms. The association could either be explained by neurodegeneration of structures related to emotional processing or to a specific dysfunction of the serotonergic system in early AD.