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P4‐095: Diffusion and morphometric MRI correlates of language function decline: A longitudinal study in dementia
Author(s) -
Frings Lars,
Mader Irina,
Weiller Cornelius,
Hüll Michael
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.2116
Subject(s) - dementia , diffusion mri , atrophy , fractional anisotropy , frontal lobe , white matter , psychology , medicine , temporal lobe , dementia with lewy bodies , pathology , audiology , neuroscience , magnetic resonance imaging , epilepsy , disease , radiology
Brain 2003 for details), setting the significance level at p (uncorrected) < 0.005. To assess subregional hippocampal atrophy, the resulting GM SPM-Tmaps were then superimposed onto the 3D representation of the hippocampi using the Anatomist/BrainVISA software, as already used (Ch etelat et al., Neuropsychologia 2008) and validated (La Joie et al., NeuroImage 2010) elsewhere.Results:Episodic encoding impairment specifically correlated with CA1 subfield GM atrophy (Figure 1B), in reference to hippocampal MRI atlas obtained frommanual delineation (La Joie et al., NeuroImage 2010 Figure 1A), but not with WM atrophy. In contrast, the weak correlation of retrieval scores with hippocampal GM did not point to a particular subfield (Figure 1C), while it was strong with WM, especially in medial parietal and frontal areas (Figure 1D). Conclusions: In aMCI patients, encoding impairment appears specifically related to GM atrophy of the CA1 hippocampal subfield, consistently with the predominant encoding deficits and predominant CA1 atrophy inMCI. In contrast, episodic retrieval deficits seem to be underlain by more distributed tissue losses, consistent with a disruption of a hippocampo-parieto-frontal network. Overall, the specific involvement of the CA1 hippocampal subfield atrophy in episodic encoding deficits in aMCI patients emphasizes this particular subfield as a potential future therapeutic target.