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P4‐092: Plasma Aβ and PET PIB binding are inversely related in mild cognitive impairment
Author(s) -
Devanand Davangere,
Schupf Nicole,
Stern Yaakov,
Parsey Ramin,
Pelton Gregory,
Mehta Pankaj,
Mayeux Richard
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.2113
Subject(s) - medicine , cerebrospinal fluid , parahippocampal gyrus , endocrinology , pittsburgh compound b , cognitive impairment , posterior cingulate , psychology , cognition , neuroscience , temporal lobe , disease , epilepsy
are total 16 gradient direction images and 1 b0 image for DTI reconstruction and b0 1⁄4 1000. The total acquisition time is roughly 15 minutes. The AAL (Automated Anatomical Labeling) template was registered with 12 degree of freedom affine transformation and 2 stage of B-Spline mutual information based non-rigid registration of the grid size of 5mm and 2.5mm deformed to our AD subject spatial space[4]. The AD subject selection is complied with the DSM-IV (Diagnostic and Statistical Manual of Mental Disorders, 4th) criteria. There are total 12 AD subjects with age of 78.92 6 6.07,MMSE of 146 6.90 and education of 2.56 4.58 yrs. In eachmedial temporal ROI, we calculate the FA, MD and AD. Results: The calculation of FA andMD can be found in [5]. The AD is the largest eigen-value ?1. The AD can avoid the situation like when?1€ Eœ?2€ Eœ?3 the magnitude of FA is still large. Table 1 shows the correlation results between brain regions with age and regions with MMSE. In correlation with age, the MD of right of amygdala, right thalamus, right of hippocampus and left of parahippocampal correlate to age well (p < 0.05). The FA-age correlations in the right of post cingulum, left of parahippocampal and right of amygdala are well. The AD-age correlations in the right of hippocampus, left of parahippocampus, right of amygdala, right of thalamus are strongly correlated. In MMSE and DTI metrics correlations, the cingulum is strongly correlated with both AD and MD. The Amygdala, parahippocampus and temporal pole are in good correlations with FA, MD and AD. Conclusions: The DTI metrics on hippocampus correlate both age and MMSE well. In the correlation between MMSE, AD and MD, cingulum shows strong correlation. The quantitative DTI metrics results demonstrate the possibility of using these metrics as the clinical criteria of discriminating the progression of AD.References: [1]M. D. Denis Le Bihan, “Diffusion Tensor Imaging: Concepts and Applications,” Journal of Magnetic Resonance Imaging, vol. 13, p. 534, 2001. [2] I. N. C. Lawes, et al., “Atlas-based segmentation of white matter tracts of the human brain using diffusion tensor tractography and comparison with classical dissection,” Neuroimage, vol. 39, pp. 62-79, 2008. [3] S. S. Mori and P. C. P. C. M. van Zijl, “Fiber tracking: principles and strategies a technical review,” NMR in Biomedicine, vol. 15, pp. 468-80, 2002. [4] G. K. Rohde, et al., “The adaptive bases algorithm for intensity-based nonrigid image registration,” Medical Imaging, IEEE Transactions, vol. 22, pp. 1470-1479, 2003. [5] C. F. Westin, “Processing and visualization for diffusion tensor MRI,” Medical Image Analysis, vol. 6, p. 93, 2002.