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P4‐086: Frontal white matter hyperintensities correlate with depressive symptoms and functionality in mild Alzheimer's patients
Author(s) -
Bilgic Basar,
Bayram Ali,
Alpsan Hale,
Tumac Ayfer,
Hanagasi Hasmet,
Sahin Huseyin,
Lohmann Ebba,
Emre Murat,
Gurvit Hakan
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.2107
Subject(s) - hyperintensity , psychology , cardiology , depression (economics) , geriatric depression scale , medicine , mood , white matter , cognitive decline , magnetic resonance imaging , cognition , psychiatry , depressive symptoms , disease , dementia , radiology , economics , macroeconomics
tients. Conclusions: Our findings corroborate the major role of the hippocampus in AD patients’ memory disorders. They also suggest that hyperactivations in ADmust be interpreted with caution andmay not systematically reflect compensatory mechanisms. Although there has been evidence supporting the existence of genuine compensatory mechanisms, dysfunction within the default mode network may be responsible for part of the apparent hyperactivations reported in the literature on AD.