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P4‐057: Characterization of flutemetamol binding in autopsy brains from [C‐11]PiB imaged subjects
Author(s) -
Ikonomovic Milos,
Abrahamson Eric,
Mathis Chester,
Price Julie,
Paljug William,
Debnath Manik,
Srinivasan Suganya,
Hamilton Ronald,
Klunk William
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.2077
Subject(s) - pittsburgh compound b , pathology , autopsy , positron emission tomography , alzheimer's disease , chemistry , dementia , amyloid (mycology) , central nervous system disease , nuclear medicine , medicine , disease
imager with the parameters including: 60 Hz motion, FOV 1⁄4 25.6 cm, 60x60 imaging matrix reconstructed to 64x64, 3x ASSET acceleration, 2.5 mm thick slices (skip 1.5 mm) and 4 phase offsets requiring 3.5 minute acquisition time (figure 1). The first harmonic data were inverted with a 3D direct inversion algorithm. The median stiffness for each individual was calculated from a global region of interest excluding SNR 30%CSF content.Results: The median stiffness of the 14 CN subjects was 2.37 kPa (range: 2.17-2.62 kPa) compared to 2.32 kPa (range: 2.18-67 kPa) within the CN + group and 2.20 kPa (range: 1.96-2.29 kPa) within the AD group. A significant difference was found between the three groups with both CN groups significantly different from the AD group (table 1). Conclusions: The results demonstrate that AD pathology alters the mechanical properties of the brain which can be measured in vivo by MRE. Brain MRE is a new imaging modality that provides a unique class of information which heretofore has not been applied to AD. Measures of brain elasticity may provide unique insights into the fundamental ultrastructural alterations in the brain that occur with AD, as well as how these change with time, correlate with other disease biomarkers and with clinical expression of the disease.