Premium
P4‐056: Mild cognitive impairment: Differential atrophy in the hippocampal subfields
Author(s) -
Hanseeuw Bernard,
Van Leemput Koen,
Kavec Martin,
Grandin Cecile,
Seron Xavier,
Ivanoiu Adrian
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.2076
Subject(s) - subiculum , hippocampus , episodic memory , atrophy , neuroscience , hippocampal formation , psychology , cognition , medicine , pathology , dentate gyrus
gional [C]PIB R1 values strongly correlate with normalized regional [F]FDG uptake (R 1⁄4 0.62 across all regions and subjects; R 1⁄4 0.73 6 0.11 across regions within subjects). A regression model including [F]FDG uptake,subject and region grouping (cortical, subcortical and limbic to allow for possible differences in flow/metabolism coupling), accounts for 86% of total [C]PIB R1 variability. Aß-load ([ 11C]PIBBPND) exhibited no significant effect on the association between [C]PIB R1 and [F]FDGuptake. Voxel-based correlation analyses with MMSE reveal very similar corefindings of positive correlation in the posterior cingulate gyrus/precuneus and negative correlations (preserved activity) in bilateral sensorimotor cortex. There was no correlation between Aß-load (BPND) and MMSE. Conclusions: These results strongly suggest that [C]PIB R1 can serve as a complementary biomarker of neuronal activity and, thus, neuronal dysfunction in addition to Aß-load given by [11C]PIBBPND. Further studies need to validate the diagnostic value of dual biomarker [C]PIBPET studies in comparison to combined [F]FDG and [C] PIB PET studies. Compared to the latter, dual biomarker [C]PIB PET imaging greatly reduces costs and burden to the patients.