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P4‐049: Investigating limbic system myelin alteration in Alzheimer's disease
Author(s) -
Deoni Sean,
Correia Steve,
Tanja Su,
Man Jessica,
Katie Lehman,
Malloy Paul,
Salloway Stephen
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.2069
Subject(s) - fornix , cingulum (brain) , white matter , anterior commissure , myelin , limbic system , diffusion mri , psychology , neuroscience , corpus callosum , pathology , fractional anisotropy , medicine , magnetic resonance imaging , hippocampus , central nervous system , radiology
related to volume differences. The first five most important shape variations are very similar (though mirrored) for left and right hippocampi. A fit model consisting of 5 hippocampal base functions and 6 rigid body parameters appears adequate to predict hippocampal shape. Conclusions: Considering that the main limiting factor, in terms of efficiency, in hippocampal shape determination in large multi centre studies is the manual segmentation procedure, we foresee that our proposed shape fitting algorithm can play an important role in future delineation tools.