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P4‐038: Ultrastructural analysis of the dark neuron formation during experimental endotoxemia: Implications for Alzheimer's disease
Author(s) -
Gasimov Eldar,
Eldar Qasimov,
Gunel Eyyubova,
Ghaffarzadagan Rafie
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.2058
Subject(s) - paraformaldehyde , pathology , nissl body , chemistry , ultrastructure , neurodegeneration , nucleus , nuclear membrane , biology , microbiology and biotechnology , staining , medicine , disease
of protein phosphatase (PP)-2A catalytic subunit at Tyrosine 307 (Y307), a crucial site regulating the activity of PP-2A, was observed in hippocampus of the transgenic mice compared to that of WTs. Furthermore, we also observed that the levels of presynaptic synaptophysin were significantly decreased but postsynaptic density protein (PSD)-95 were not significantly altered in hippocampus of the transgenic mice.Conclusions:Our data indicate that the PS-1 mutation can induce Alzheimer-like tau hyperphosphorylation and synaptic degeneration, as well as increased production of As.