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P4‐009: Decrease of PTEN expression levels among normal, symptomatic and asymptomatic Alzheimer's disease (Ad) subjects, measured in hippocampus, temporal and entorhinal cortices.
Author(s) -
Feio dos Santos Ana Cecília,
Silva Aderbal,
Grinberg Lea,
Farfel Jose,
Ferretti Renata,
Ferreira Begnami Maria Dirlei,
Rocha Rafael,
Soares Fernando,
Brentani Helena
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.2028
Subject(s) - pten , hippocampus , dementia , asymptomatic , neurodegeneration , medicine , pathology , alzheimer's disease , disease , pi3k/akt/mtor pathway , endocrinology , biology , neuroscience , apoptosis , genetics
was gathered exclusively through clinical information and neuropathological features typical of vascular and Lewy bodies dementia were included in the analysis. The objective of the current study was to examine whether the association between neuropathological features related to AD and dementia varies in the very-old group (age 1⁄4 80 years) compared to the young-old group (age1⁄4 79 years).Methods:A post-mortem study evaluating individuals 1⁄4 60 years, included in the Brazilian Aging Brain Study. Cognitive evaluation was gathered with a semi-structured interview with the next of kin informant using the CDR and the IQCODE. Individuals were classified as cognitively normal if the CDR 1⁄4 0 and the IQCODE < 3.20 and as demented if the CDR 1⁄4 2 and the IQCODE > 3.80. Neuropathological examinations were carried out based on accepted criteria, using immunohistochemistry. All subjects were classified according to Braak & Braak staging, CERAD and the NIA-RI criteria. ROC analysis were preformed to evaluate the predictive value of each neuropathological feature in both intervals of age. Results: We examined 360 individuals. Of the participants 52.5% were female, 66.4% were classified as CDR 1⁄4 0, 12.5% as CDR 1⁄4 2 and other 21.1% as CDR 1⁄4 3 and 41,1% were 1⁄4 80 years. The relationship between AD-type neuropathological features and dementia were not different among the Young-old compared to the very-old group. Braak & Braak staging was considered the most predictive feature in both groups (ROC area under the curve 0.75, 0.61-0.89, p< 0.01 for the very-old and 0.73, 0.52-0.93, p 1⁄4 0.04 for the young-old group). The NIA-RI (ROC area 0.59, 0.43-0.73 and 0.67, 0.46-0.87 for the very-old and young-old, respectively) and the CERAD criteria (ROC area 0.53, 0.36-0.70 and 0.66, 0.45-0.87 for the very-old and young-old, respectively) did not reach statistical significance as predictors. Conclusions: Neruopathological features related to AD demonstrate the same predictive value for dementia in the very-old compared to the young-old. Braak & Braak staging is the most predictive neuropathological feature in both groups of age.