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S1‐01‐05: Genome‐wide association studies of CSF biomarkers
Author(s) -
Kauwe John,
Cruchaga Carlos,
McKean David,
Bailey Matthew,
Patty David,
Mayo Kevin,
Bertelsen Sarah,
Hinrichs Anthony,
Fagan Anne,
Holtzman David,
Goate Alison
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.202
Subject(s) - single nucleotide polymorphism , genome wide association study , snp , genetic association , apolipoprotein e , genetics , biology , genotype , candidate gene , disease , gene , medicine
and/or genes which are only nominally associated with the disease risk using two different tools (the ALIGATOR and GenGen/KEGG software packages). Convergent outputs from the two gene set enrichment approaches suggested an immune system dysfunction in AD.We finally developed tight collaborations with other consortia through the IGAP (International Genomics Alzheimer Project), all aiming at increasing statistical power for the discovery of most of the genetic determinants of Alzheimer’s disease. Conclusions: After a long period of stagnation, high-throughput genomic technologies have seriously stimulated our understanding of the genetics bases of AD. Within this rapidly changing technical and methodological context, one can expect the general picture of AD genetics to continue to be massively modified over the next few years. This will probably lead to the discovery of unexpected genes and to the exclusion of a large proportion of older promising genes as AD genetic determinant. Last but not least, the current GWAS-defined genes are already opening up new perspectives in the AD pathophysiological process, for instance suggesting a potential dysfunction of Ab clearance.