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IC‐P‐177: The IMAP∗ project: the paradox of the posterior cingulate cortex in Alzheimer's disease: Atrophic, hypometabolic, but still able to show preserved fMRI activity during a self‐related task
Author(s) -
Villain Nicolas,
Desgranges Béatrice,
Morel Nastassja,
Mézenge Florence,
La Joie Renaud,
Fouquet Marine,
Mevel Katell,
Perrotin Audrey,
Landeau Brigitte,
La Sayette Vincent,
Viader Fausto,
Eustache Francis,
Chételat Gaël
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.191
Subject(s) - posterior cingulate , statistical parametric mapping , atrophy , neuroimaging , psychology , neuroscience , alzheimer's disease neuroimaging initiative , cortex (anatomy) , cognitive impairment , functional neuroimaging , alzheimer's disease , cognition , cardiology , disease , medicine , audiology , magnetic resonance imaging , radiology
ican National Adult Reading Test (AMNART) was used as a measure of environmental enrichment provided by educational and occupational attainment, a component of cognitive reserve. Results: Among CN, none of the biomarkers correlated with the measures of cognition whereas AMNARTwas significantly correlated with Boston naming and MMSE. Incognitively-impaired subjects, AMNART and all biomarkers of neuronal pathologyand amyloid loadwere independently correlatedwith all cognitive measures.Exceptions to this general conclusion were absence of correlation between CSFAß1-42 and Boston naming and Trails B. In contrast, WMH were only correlated with Boston naming and Trails B in the cognitively-impaired. When all subjects were included in a flexibleordinal regression model that allowed for nonlinear effects and interactions, we found that AMNART had an independent additive association such that better AMNART performance was associated with better cognitive performance across the biomarker distribution (Fig.1). Conclusions: 1) In CN, the variability in cognitive performance isexplained partly by AMNARTand not by biomarkers of AD. 2) In cognitively-impairedsubjects, AMNART, biomarkers of neuronal pathology and amyloid load all independently explain variability in cognition. 3) Finally, the association between cognition and AMNARTwas found to be additive rather than to interact with biomarkers of AD (illustrated in Fig.2).