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IC‐P‐176: Cognitive reserve and Alzheimer's disease biomarkers are independent determinants of cognition
Author(s) -
Vemuri Prashanthi,
Weigand Stephen,
Przybelski Scott,
Knopman David,
Smith Glenn E.,
Trojanowski John,
Shaw Leslie,
DeCarli Charlie,
Carmicheal Owen,
Bernstein Matt,
Aisen Paul,
Weiner Michael,
Petersen Ronald,
Jack Clifford
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.190
Subject(s) - cognitive reserve , cognition , psychology , dementia , atrophy , boston naming test , audiology , cognitive decline , hyperintensity , neuroscience , abnormality , alzheimer's disease , neuropsychology , cognitive impairment , disease , medicine , pathology , magnetic resonance imaging , psychiatry , radiology
Behavior item. In a followup analysis, we examined correlations between Agitation factor score and metabolism in the three cortical volumes identified in the SPM analysis. Agitation factor score was inversely correlated with metabolic activity in each (rs 1⁄4 0.35 0.36; p < .001), indicating that symptom severity is associated with the extent of hypometabolism. Conclusions: Dysfunction in right temporal/midfrontal and bilateral cingulate cortex contributes to angry, irritable, and hostile behavior in AD, but impulsive, disinhibited, and repetitive motor behaviors may not localize to discrete cortical circuits in AD. Distinct biomarkers for specific “agitated” behaviors can reveal intermediate phenotypes that can improve understanding of behavioral phenomenology and promote optimal interventions in AD.