P3‐443: All‐trans retinoic acid treatment of Alzheimer's disease transgenic mice | Zendy

Lerner Alan | Zendy; GustawRothenberg Katarzyna | Zendy; Casadesus Gemma | Zendy; Smith Mark | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

P3‐443: All‐trans retinoic acid treatment of Alzheimer's disease transgenic mice

Author(s) -

Lerner Alan,

GustawRothenberg Katarzyna,

Casadesus Gemma,

Smith Mark

Publication year - 2011

Publication title -

alzheimer's and dementia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.713

H-Index - 118

eISSN - 1552-5279

pISSN - 1552-5260

DOI - 10.1016/j.jalz.2011.05.1887

Subject(s) - morris water navigation task , retinoic acid , genetically modified mouse , saline , retinoid , pharmacology , chemistry , medicine , transgene , endocrinology , biochemistry , hippocampus , gene

attenuated, in the dose-range tested, the hyperphosphorylation of tau on physiological epitopes (AT-8 antiboby clone) and on pathological epitopes (AT-100 clone). Conclusions: These experiments showed that the mixed muscarinic and sigma-1 receptors ligand attenuated the tauopathy through activation of the PI3K/P-AKT/GSK-3ß pathway in the oAß model of AD, confirming its potent neuroprotective activity.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research