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P3‐443: All‐trans retinoic acid treatment of Alzheimer's disease transgenic mice
Author(s) -
Lerner Alan,
GustawRothenberg Katarzyna,
Casadesus Gemma,
Smith Mark
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.1887
Subject(s) - morris water navigation task , retinoic acid , genetically modified mouse , saline , retinoid , pharmacology , chemistry , medicine , transgene , endocrinology , biochemistry , hippocampus , gene
attenuated, in the dose-range tested, the hyperphosphorylation of tau on physiological epitopes (AT-8 antiboby clone) and on pathological epitopes (AT-100 clone). Conclusions: These experiments showed that the mixed muscarinic and sigma-1 receptors ligand attenuated the tauopathy through activation of the PI3K/P-AKT/GSK-3ß pathway in the oAß model of AD, confirming its potent neuroprotective activity.