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P3‐437: Enhanced muscarinic receptor responses in vitro after multi‐nutrient supplementation
Author(s) -
Savelkoul Paul,
Merkes Mandy,
Janiekova H,
Kuipers Almar,
Hageman Robert,
Dolezal Vladimir,
Broersen Laus,
Kamphuis Patrick
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.1881
Subject(s) - muscarinic acetylcholine receptor , receptor , chemistry , calcitriol receptor , choline , muscarinic acetylcholine receptor m1 , biochemistry , microbiology and biotechnology , endocrinology , medicine , biology
Alzheimer's disease (AD) is a progressive neurodegenerative disease and it's clear that in addition to Abeta plaque and tangle formation, loss of dendritic spines and synaptic connections are a hallmark of AD. Previous work has demonstrated that nutrients such as DHA, EPA, UMP, choline, vitamins B6 and B12, folate, phospholipids (PLs), vitamin C and E, and selenium act synergistically in improving synapse formation. This specific combination of nutrients, combined in FortasynTMConnect, was tested in a proofof-concept clinical study that resulted in memory improvement in mild AD patients (Scheltens2010). In addition, activation of muscarinic receptors has been shown to stimulate non-amyloidogenic APP processing, possibly by facilitating synapse formation.
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