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IC‐P‐166: Neural correlates of the stroop test performance in patients with Alzheimer's disease: A FDG‐PET study
Author(s) -
Lee Dong Young,
Seo Eun Hyun,
Yun JeYeon,
Choo Il Han,
Park Shin Young,
Kim Shin Gyeom,
Woo Jong Inn
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.180
Subject(s) - stroop effect , voxel , audiology , statistical parametric mapping , correlation , orbitofrontal cortex , neural substrate , anterior cingulate cortex , psychology , prefrontal cortex , precuneus , medicine , neuroscience , functional magnetic resonance imaging , magnetic resonance imaging , cognition , radiology , geometry , mathematics
pDMN and aDMN in a large sample of 341 cognitively normal elderly participants. We then examined the connectivity differences in the pDMN and the aDMN between 56 cognitively normal (CN) non-carriers of the apolipoprotein E e4 allele rigorously matched on age, gender, and education to 28 AD patients. Methods: Subjects underwent standard EPIBOLD fMRI scanning, while only instructed to keep their eyes open. Analyses were performed with SPM5, resting-state fMRI data analysis toolkit, and group ICA of fMRI toolbox software. The age effect on ICA results for the aDMN and pDMN was derived using age as a linear covariate (N 1⁄4 341). Comparison between AD (N 1⁄4 28) and CN (N 1⁄4 56) for both ICA and seed-based analysis (controlling for gray matter density) was done using a two sample t-test. The short test of mental status (STMS) scores for every subject was used as a covariate in a linear regression analysis for each group. Results: The pDMN shows age-associated decreases in connectivity in the posterior cingulate cortex, precuneus, inferior parietal lobule, and increased connectivity in the left temporo-parietal region. Conversely, the aDMN displays both increased and decreased connectivity in the frontal lobe (figure 1). The group comparison between CN and AD reveals a pattern similar to the age effect (with AD appearing more advanced in age) (figures 2 and 3). The pDMN connectivity is associated with higher STMS scores. The aDMN connectivity posteriorly is also associated with higher scores, and higher frontal lobe connectivity is associated with worse scores.Conclusions: These results support our hypothesis that the DMN abnormalities observed in AD are qualitatively similar to those seen in aging, and suggest they may relate to greater synaptic inefficiency in the aging AD brain.