Premium
P3‐333: Early cognitive impairment sex difference in treated hypertensive patients
Author(s) -
TarnovskaKadreva Rumiana,
Traykov Latchezar
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.1776
Subject(s) - medicine , dementia , population , blood pressure , vascular dementia , cognitive decline , disease , pediatrics , environmental health
Background: Hypertension is a major risk factor for both vascular and Alzheimer typedementia. Some dementia studies postulate that there are sex differences in the Alzheimer disease and vascular dementia morbidity. Are there sex differences in the frequency of early cognitive impairment (CI) in hypertensive patients (Pts)and is one of the sexes at a higher risk? Recent data showed that in some cardiovascular studies both sexes are not equally represented or lack gender specific statistics. The analysis of the sex difference in early CI intreated hypertensive Pts is part of a prospective study in this group of patients. Methods: We examined 51 (34.5%) males and 97 (65.5%) females, a total of 148 Pts with mean age 64.16611.18 years and mean hypertension history 13.1611.05 years. We gathered full medical history, esp. hypertension history, physical examination and laboratory screening. Pts with atrialfibrillation, major head trauma, bypass surgery and neurological disease leading to CI were excluded. Neuropsychological profile was assessed with a battery of neuropsycological tests (NPTs), validated for the Bulgarian population: Mini-Mental State Examination (MMSE, cut-off value 25) and the more sensitive and specific Montreal Cognitive assessment (MoCA, cut-off value 26). Ambulatory blood pressure monitoring (ABPM) was conducted as recommended by ESH/ESC. Results: Mann-Whitney test was used to assess the difference in NPTs’ results between sexes. At level of significance < 0.05 we found that there isn’t any significant difference between males and females (in the whole group and in an age intervals of 10 years) in NPTs’ results. Mean values of NPTs were: formales MMSE 27.8062.78 and MoCA 25.09863.21, for females MMSE 27.6662.71 and MoCA 24.1164.097). We used dispersion analysis to find that the sex is not a factor for early CI. We used Mann-Whitney test to find significant difference (< 0.05) in NPTs’ results in both sexes between groups with different ABPM variables and BP target values. Conclusions: There is correlation between some ABPM variables and CI, which is not gender dependent. There isn’t any significant difference in the frequency of early CI between males and females. On the basis of these results we conclude that early CI screening and dementia prevention in hypertensive Pts is useful and should be conducted routinely in both sexes.